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Neamine tetrahydrochloride

CAS No. 15446-43-2

Neamine tetrahydrochloride( —— )

Catalog No. M34822 CAS No. 15446-43-2

Neamine tetrahydrochloride is a broad-spectrum aminoglycoside antibiotic with antibacterial, antitumor and neuroprotective activities, inhibits the growth of pancreatic cancer cells, and inhibits the proliferation of oral cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Neamine tetrahydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Neamine tetrahydrochloride is a broad-spectrum aminoglycoside antibiotic with antibacterial, antitumor and neuroprotective activities, inhibits the growth of pancreatic cancer cells, and inhibits the proliferation of oral cancer cells.
  • Description
    Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.
  • In Vitro
    Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.:Cell Proliferation Assay Cell Line:AsPC-1 cells Concentration:0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 25 μM Incubation Time:48 hours Result:Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
  • In Vivo
    Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.Animal Model:Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells Dosage:30 mg/kg, 60 mg/kg Administration:Subcutaneous injection; daily; for 14 days Result:Had anti-tumor effects on AsPC-1 xenograft models.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antibiotic
  • Recptor
    Antibiotic | Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    15446-43-2
  • Formula Weight
    468.2
  • Molecular Formula
    C12H30Cl4N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O[C@H]([C@H]([C@@H](C[C@@H]1N)N)O)[C@@H]1O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2N)O)O)CN.Cl.Cl.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.?
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